People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. J Diabetes Res. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). What Are the Risks of Taking Milk Thistle? Osteoporosis is a disease caused by progressive bone loss. However, as this is the only study, more high-quality research is needed. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. . All rights reserved. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. The terms "milk thistle" and "silymarin" are often used interchangeably. The nutritional content varies for each brand, so be sure to . 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Its not known whether milk thistle is helpful for other conditions. 2. Other studies looking at milk thistle for cirrhosis have found conflicting results. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . If you are a Mayo Clinic patient, this could Do not take milk thistle without medical advice if you are using a medication to treat any of the following conditions: any type of infection (including HIV, malaria, or tuberculosis); arthritis pain, occasional pain, or tension headaches (including Advil, Motrin, or Celebrex); heartburn or gastroesophageal reflux disease (GERD); high blood pressure, high cholesterol, or a heart condition; psoriasis, rheumatoid arthritis, or other autoimmune disorders; This list is not complete. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. Milk thistle extract has a high amount of silymarin (between 6580%) that has been concentrated from the milk thistle plant. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Phytother Res. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. . Milk thistle may interact with certain medications and supplements. Do not use this product without medical advice if you are breast-feeding a baby. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Written by Cerner Multum. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. https://www.nccih.nih.gov/health/milk-thistle. The site is secure. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Call 911 or seek help right away if you experience severe side effects from taking milk thistle. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Is There a Reason Your Milk Thistle Isn't Working? (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Accessed Oct. 30, 2020. If we combine this information with your protected Milk thistle may be useful in treating liver disease, cancer, and diabetes. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). Some of the studies have been of poor quality, too. Here are 7 science-based benefits of milk thistle. Fluoxetine is whats known as a selective serotonin reuptake inhibitor (SSRI) which aims to increase serotonin levels in the brain. Verywell Health's content is for informational and educational purposes only. In: Textbook of Natural Medicine. One study questioned the benefits of milk thistle for liver diseases. Silybum marianum (milk thistle). As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Minerals for OCD Milk thistle may not be recommended in some situations. In: Drugs and Lactation Database (LactMed). 2005 - 2023 WebMD LLC, an Internet Brands company. 2022 Dec 7;19(24):16426. doi: 10.3390/ijerph192416426. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. Scan J Gastroenterol. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. Exercise caution and start slow. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Do not use more of this product than is recommended on the label. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Phytomedicine. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. Generic name: milk thistle [MILK-THIH-sull] Milk thistle is a safe supplement that shows potential as a complementary therapy for various conditions, including liver disease, cancer and diabetes. As a result of excessive alcohol consumption, my liver was fattened and my enzymes increased. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Int J Mol Sci. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Pizzorono JE, et al., eds. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. . Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. Although rare, milk thistle may trigger a number of common and mild side effects. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; This is not a complete list of side effects and others may occur. Milk thistle has not been shown to treat or prevent cancer or reduce the side effects of cancer treatment. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). https://naturalmedicines.therapeuticresearch.com. Milk thistle can cause severe allergic reaction and anaphylaxis, a rare but potentially life-threatening allergic reaction. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. Eur Endocrinol. Keywords: It is primarily considered a cleansing agent and used to block or flush toxins from the body. Accessed Oct. 30, 2020. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. J Tradit Complement Med. Epub 2023 Mar 4. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver. Unauthorized use of these marks is strictly prohibited. Milk thistle should not be used in place of medication prescribed for you by your doctor. Nevertheless, pregnant women, those allergic to the Asteraceae family of plants, those with diabetes and anyone with an estrogen-sensitive condition should seek medical advice before taking it. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Version: 2.01. Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. MeSH Eighteen clinical trials of 1,088 participants were assessed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. include protected health information. It is not certain whether milk thistle is effective in treating any medical condition. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. Liver Detoxification and Health. We comply with the HONcode standard for trustworthy health information. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). This publication is not copyrighted and is in the public domain. doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Tadaah, perhaps a partly explanation for your experience? 8600 Rockville Pike Biomed Res Int. Its thought to work by making more of the milk-producing hormone prolactin. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. There is a problem with 2023 Natural Wellness. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Website: https://pubmed.ncbi.nlm.nih.gov/. Our study provides a new insight into the protective effects of silibinin in the treatment of anxiety/depression. Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. Studies have shown improvements in liver function in people with liver diseases who have taken a milk thistle supplement, suggesting it could help reduce liver inflammation and liver damage (9). Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Drug class: Herbal products. People have traditionally used milk thistle for problems with the liver and gallbladder . CNS Neurosci Ther. It may have protective effects on the liver, preventing damage. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Pharmacol Rev. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Disclaimer. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. And Selenium too. Milk thistle is a popular herbal remedy best known for its liver-protecting properties. While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). To ensure quality and potency in your herbal remedies, why not grow your own? Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. There are other supplements that work similarly to milk thistle. eCollection 2022. Large-scale, properly-designed studies are needed. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Historically, people have used milk thistle for liver disorders and gallbladder problems. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles. *These statements have not been evaluated by the Food and Drug Administration. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. health information, we will treat all of that information as protected health Unable to load your collection due to an error, Unable to load your delegates due to an error. Bethesda, MD 20894, Web Policies New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). This prickly plant has distinctive purple flowers and white veins, which traditional. Some medications have been known to interact with milk thistle negatively. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Milk thistle. Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. National Library of Medicine Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. 2016;5147468. doi:10.1155/2016/5147468. Front Immunol. privacy practices. The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). What Are the Side Effects of Milk Thistle? Side effects are always possible when taking supplements. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. NCCIH has provided this material for your information. Elsevier; 2021. https://www.clinicalkey.com. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Epub 2016 Dec 22. the unsubscribe link in the e-mail. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. . Its herbal remedy is known as milk thistle extract. Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3).
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