Infertility Support Community in Partnership with RESOLVE. My lining a week before transfer was 6.8, but trilaminar lining was present. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. Then my 3rd transfer and 2nd FET is now my baby boy growing well at 16 weeks 4 days. I had another hysteroscopy after my chemical but b/c it had been nearly 2 years since I had one when i started IVF. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome.So no one knew what was being transferred. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. I actually didn't do acupuncture the second cycle, but I was in great shape. However, these differences were not found in women older than 30 years. Please can you offer a perspective? Did you get your BFP on IVF post the antibiotics or naturally? (2017)found no difference in survival rates of embryos that were thawed and biopsied, then refrozen. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. What would they tell me and how would they impact protocol differently? I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. Sending you positive thoughts . He also answers questions in his private Facebook group. I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. I am terrified he wont implant. Note that this post is current as of July 2022. 5AB euploid embryo. Kelly. I also did Neupogen but they still wanted to test for autoimmune disorders. , Ive done embryo glue every transfer but no luck unfortunately :(. We had 30 eggs retrieval. I asked her can we do bloodwork to see what couldve caused the miscarriage (I.e immune complex, blood clotting disorder or inflammation) and she doesnt think I need to and how we should proceed with the same protocol again and I dont know how to feel about this unable to sleep. (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. Whitney et al. Best of luck on your next FET! As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. I am so frustrated, disappointed, hurt, sad and angry right now. My current success was a FET with NO meds except vaginal progesterone. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. So what if the embryos are euploid? This is important because miscarriage rates with advancing female age. Sounds like a beautiful a rainbow miracle! , dont be sorry! Low mosaics had a miscarriage rate of 11.0%, None of these were statistically significant from the other (, Euploid embryos had an 8.6% miscarriage rate, All of the mosaics had a 20.4% miscarriage rate, <50% mosaic segmental embryos had a 13.6% chance of miscarriage, >50% mosaic segmental embryos had a 20.3% chance of miscarriage, <50% two whole chromosome mosaics had a 11.9% chance of miscarriage, <50% complex (>2 whole chromosomes) mosaics had a 26.7% chance of miscarriage, >50% two whole chromosome mosaics had a 39.9% chance of miscarriage, >50% complex (>2 whole chromosomes) mosaics had a 44.3% chance of miscarriage. Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. So what gives now?? 1st IVF Cycle with initial low beta results, Day 6 Blastocysts / PGS / embryo "Hunger Games". Thanks! Live birth rate differences are inconsistent and therefore inconclusive. Some of the reasons quoted weren't even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, there's a margin of error with the testing itself, pgs doesn't tell us everything about an embryo, etc. Design: Case-control study. This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. We have our lining check on Friday. Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. Reply Share React operationpepper Dec 22, 2015 3:42 PM Women who have three chromosomally-normal embryos as a result of In Vitro Fertilization (IVF) have a 94.9% chance of achieving pregnancy, research conducted by Reproductive Medicine Associates (RMA) and presented at the annual meeting of the American Society for Reproductive Medicine (ASRM) shows. Your clinic may have a better idea! Im hoping to do another transfer in January. I will look into this and mention to my doctor :) Ive been taking 10mg of prednisone but Ive never taken Lovenex. Im so sorry to hear about your losses but so happy with your current miracle. no, I just took those 3. For women who have it, REs may suggest prednisone and lovenox after transfer. I might actually look into that. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. Chemical pregnancy with PGS tested embryo. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. Causes of a chemical pregnancy. is there another clinic in your area you can switch to? Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Ill have to ask my RE for options. Chemical pregnancy facts. I'm so sorry for your loss. sd84. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. I miscarried a genetically normal baby girl at 8.5 weeks and they tested me for autoimmune disorders so that could be something to check for as well. Did our first FET in October with a supposedly PGT normal embryo. I did acupuncture that cycle. Your story does give me hope and I wish my little one is as strong as yours! He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Well start with euploids, then mosaics, and end with fully aneuploid embryos. (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). But after this chemical pregnancy from our PGS embryo, I have a gut feeling there is something else at play and am pushing my doctor for additional testing before another transfer since we only have 3 embryos left after 2 IVF cycles. Which was Claritin, pepcid, and baby aspirin. I will ask my dr about this. 2) I feel like I've turned over every stone in trying to figure out what is wrong; does anyone have insight into how one would determine whether the problem is with the egg or with my body? So weve been ttc for almost 2 years. For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. I dont know if this is helpful or not but Ive had 4 FETs. PGS can increase the rate of clinical pregnancy. Capalbo et al. Advancing age of the female partner increases the chance that the embryo will be abnormal. Also - wanted to add that I think my husband and I both did antibiotics still with our new clinic. About 7 months later I transferred a day 7. With the second, the only change was to add low dose steroids. (2018)found a reduction in clinical pregnancy when embryos were thawed, biopsied and re-frozen (the odds were about half). Thanks in advance! Check here for the full. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. A few rounds of heavy- duty antibiotics cleared it up. Youre right! I encourage to keep pushing forward. She said she is willing to do so but against her medical advice. Congratulations on your success , I have a similar story. Every positive thing helps! Do embryo biopsies for PGT-A match the rest of the embryo? This study is considered the best quality evidence currently available for PGT-A (which showed no benefit over traditional grading for women <35 that you read about that here). My FET is at the beginning of June so hoping that with this adjustment, a better outcome will occurs. Create an account or log in to participate. Group Black's collective includes Essence, The Shade Room and Naturally Curly. also did you have to do another stim cycle? Any advice is greatly appreciated. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. We are currently looking to use a gestational surrogate in Texas. If your protocol did not have one or the other perhaps you can ask your RE about it. Mosaics are often transferred after euploid embryos have been exhausted, although there is evidence that low level mosaic transfers are comparable to euploid transfers (see here for a review). (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). Or they did but they were all aneuploid? I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. All 3 embryos made it to day 5 blastocyst on the 6th day we did pgs testing. I know she's going to ask me whether I want to proceed or not unless these 3 follicles really change overnight, of which I'm not getting my hopes up. Good luck! We have some sort of make factor at play but no other known fertility issues. On September 20th, we did my first IVF cycle. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. So they were both frozen on Day 6? It looks like at this time that it's implantation failure rather than abnormal embryos, since we got a good one from the ones we had tested. This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). It definitely won't hurt to ask your doctors about an antihistamine protocol, I don't remember the exact dosages I took or how long. Please specify a reason for deleting this reply from the community. The other two are on ice. We put both in and im currently 8weeks pregnant. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Is it significantly less for a pregnancy with an embryo that tested pgt normal? The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. I was doing yoga and walking everyday and meditating. If you have not I would suggest an embryo scratch/biopsy before your next FET. I have had my heart broken multiple times. We spent well over 45K to get to this point. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. Dear T3BK, thank you so much for your reply!